Selected recent publications from the Broderick lab:

William E. Broderick, Brian M. Hoffman, Joab B Broderick, “Mechanism of Radical Initiation in the Radical S-Adenosyl-L-methionine Superfamily,” Acc. Chem. Res. 2018, 51(11), 2611–2619.
10.1021/acs.accounts.8b00356

Amanda S. Byer, Hao Yang, Elizabeth C. McDaniel, Venkatesan Kathiresan, Stella Impano, Adrien Pagnier, Hope Watts, Carly Denler, Anna L. Vagstad, Jorn Piel, Kaitlin S. Duschene, Eric M. Shepard, Thomas P. Shields, Lincoln G. Scott, Edward A. Lilla, Kenichi Yokoyama, William E. Broderick, Brian M. Hoffman, and Joan B. Broderick, “Paradigm shift for radical S-adenosyl-l-methionine reactions: the organometallic intermediate Ω is central to catalysis,” J. Am. Chem. Soc. 2018, 140, 8634-8638. 10.1021/jacs.8b04061

Anna G. Scott, Robert K. Szilagyi, David W. Mulder, Michael W. Ratzloff, Amanda S. Byer, Paul W. King, William E. Broderick, Eric M. Shepard, and Joan B. Broderick, “Compositional and structural insights into the nature of the H-cluster precursor on HydF,” Dalton Trans. 2018, 47, 9521-9535. 10.1039/c8dt01654b

Eric M. Shepard, Amanda S. Byer, and Joan B. Broderick, “Iron-Sulfur Cluster States of the Hydrogenase Maturase HydF,” Biochemistry 2017, 56, 4733-4734.  10.1021/acs.biochem.7b00735

Krista A. Shisler, Rachel U. Hutcheson, Masaki Horitani, Kaitlin S. Duschene, Adam V. Crain, Amanda S. Byer, Eric M. Shepard, Ashley Rasmussen, Jian Yang, William E. Broderick, Jessica L. Vey, Catherine L. Drennan, Brian M. Hoffman, and Joan B. Broderick, “Monovalent cation activation of the radical SAM enzyme pyruvate formate-lyase activating enzyme,” J. Am. Chem. Soc. 2017, 139, 11803-11813.  10.1021/jacs.7b04883

 

Eric M. Shepard, Amanda S. Byer, Priyanka Aggarwal, Jeremiah N. Betz, Anna G. Scott, Krista A. Shisler, Robert J. Usselman, Gareth R. Eaton, Sandra S. Eaton, and Joan B. Broderick, “Electron spin relaxation and biochemical characterization of the hydrogenase maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] cluster communication and hydrogenase activation,” Biochemistry 2017, 56, 3234-3247.  10.1021/acs.biochem.7b00169

Eric M. Shepard, Amanda S. Byer, Jeremiah N. Betz, John W. Peters, and Joan B. Broderick, “A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF,” Biochemistry 2016, 55(25), 3514-3527.  10.1021/acs.biochem.6b00528

Masaki Horitani, Krista Shisler, William E. Broderick, Rachel U. Hutcheson, Kaitlin S. Duschene, Amy R. Marts, Brian M. Hoffman, and Joan B. Broderick, “Radical SAM catalysis via an organometallic intermediate with an Fe-[5’-C]-deoxyadenosyl bond,” Science 2016, 352(6287), 822-825.  10.1126/science.aaf5327

Masaki Horitani, Amanda S. Byer, Krista A. Shisler, Tilak Chandra, Joan B. Broderick, Brian M. Hoffman, “Why Nature uses radical SAM enzymes so widely: ENDOR studies of lysine 2,3-aminomutase shows the 5’-dAdo• ‘Free Radical’ is never free,” J. Am. Chem. Soc. 2015, 137(22) , 7111 – 7121.  10.1021/jacs.5b00498